Ear Nose Throat J. 2020 Feb;99(2):94-95. doi: 10.1177/0145561319871711.
FIRST PARAGRAPH: Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (originally called HPV-related carcinoma with adenoid cystic-like features) is a recently recognized variant of sinonasal carcinoma showing histologic features of surface dysplasia and salivary gland carcinoma (adenoid cystic carcinoma specifically) and showing a strong association with HPV, especially HPV 33. Women are affected slightly more often than men, with a mean age at presentation in the sixth decade, frequently with high T-stage disease. Tumors involve the nasal cavity and paranasal sinuses, often with extension into adjacent structures. Even though the tumors are often large and destructive sinonasal tract tumors, they tend to exhibit a relatively indolent behavior, although local recurrence is frequent, but distant metastasis and death from disease are very uncommon. As such, this tumor should be distinguished from histologic mimics as there is a better prognosis.
PubMed ID: 31476886
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