Prognostic impact of retropharyngeal lymphadenopathy in early-stage HPV-associated oropharyngeal cancer: Implications for staging optimization

Head & Neck, Oropharynx
Bhattasali O, Torres FA, Kang HK, Thompson LDR, Abdalla IA, McNicoll MP, Lin A, Ryoo JJ, Chen J, Iganej S.
Oral Oncol. 2021 Mar;114:105147. doi: 10.1016/j.oraloncology.2020.105147. Epub 2021 Jan 16.
FIRST PARAGRAPH: Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is established as a disease with generally favorable outcomes, particularly when contrasted to other head and neck squamous cell carcinomas which are commonly associated with heavy alcohol and tobacco use [1,2]. Prior cancer staging systems did not accurately prognosticate outcomes for HPV-associated OPSCC. Consequently, the American Joint Committee on Cancer (AJCC) 8th edition staging system reclassified HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) as its own entity and adapted the risk-stratification system proposed by the ICON-S group for this cohort of patients [3].
PubMed ID: 33460883
Article Size: 1 MB