Ear Nose Throat J. 2021 Sep;100(5_suppl):540S-541S. Doi: 10.1177/0145561319871712.
FIRST PARAGRAPH: Verrucous squamous cell carcinoma (VSCC), sometimes called Ackerman tumor, is a highlight differentiated, lowgrade squamous cell carcinoma (SCC) variant that is characterized by an exophytic, warty growth, and a broad, pushing border of infiltration below the level of the adjacent uninvolved epithelium basement membrane, comprised of cytologically bland, amitotic squamous epithelium. As a SCC variant, it is strongly associated with tobacco and alcohol abuse. The vast majority of tumors are identified in the oral cavity (Figure 1), with the remaining tumors identified in the larynx, sinonasal tract, and pharynx. Women are affected more often than men by oral cavity tumors, with the reverse in the larynx. Patients present in the sixth and seventh decades of life with large tumors are seen as broad-based, fungating, exophytic, firm masses, generally lacking ulceration. Conservative surgery is usually employed without neck dissection or radiation to achieve an excellent >90% 5-year survival.
PubMed ID: 31760791
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