Ear Nose Throat J. 2021 Sep;100(5_suppl):531S-532S. doi: 10.1177/0145561319890153.
FIRST PARAGRAPH: IgG4-related sialadenitis, formally Ku¨ttner tumor, is a chronic fibroinflammatory tumefactive salivary gland disorder characteristically showing dense lymphoplasmacytic infiltrate, storiform fibrosis, phlebitis, and increased IgG4-positive plasma cells, often with elevated serum IgG4 concentrations. This immune-mediated disorder often has systemic findings, including autoimmune pancreatitis, retroperitoneal fibrosis, cholangitis, lacrimal gland dacryoadenitis, Riedel thyroiditis, and other glands affected by a similar inflammatory fibroblastic disorder. The disorder is characterized by a prominent lymphoplasmacytic infiltrate and cytotoxic T-cell populations. In some submandibular cases, sialolithiasis may be a confounding factor.
PubMed ID: 31760789
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