Ear Nose Throat J. 2021 Sep;100(5_suppl):520S-521S. doi: 10.1177/0145561319890165.
FIRST PARAGRAPH: Inflammatory myofibroblastic tumor (IMT) is a distinctive, rarely metastasizing, (myo)fibroblastic neoplasm composed of spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and/or eosinophils. Genetically, most IMTs harbor tyrosine kinase fusions, usually the ALK gene with an ever-expanding list of partner genes (TIMP3-ALK is most common), although these rearrangements are rare in adults. More common in abdominal soft tissue and lung sites, head and neck tumors comprise about 20% of all IMTs. Children and young adults are usually affected, with a slight female predominance. Symptoms are nonspecific and generally related to obstructive symptoms due to mass effect. Patients are generally managed surgically, although molecular-targeted therapy (eg, crizotinib) shows good response. While metastatic disease is exceptional, local recurrences are seen in about 25% of patients.
PubMed ID: 31760795
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